LSD

Episode 72: When The Trip Doesn’t End with Ed Prideaux

May 28, 2022 Narcotica Episodes, Psychedelics 01:17:41 0 Comments

Psychedelics and other drugs can trigger a condition called Hallucinogen Persisting Perception Disorder, a terrible name for a real condition that we don’t have much data on and is poorly understood. But while it’s clear that psychedelics shouldn’t be illegal, it’s also clear we’re still learning about some of the risks. This fascinating and often distressing phenomenon deserves a closer look, but not everything about it is devastatingly tragic, either.

In this episode of Narcotica, co-host Troy Farah talks all about HPPD with Ed Prideaux, a master’s student in psychology at the University of East London with a background in journalism. Ed is currently focused on researching and addressing the problems, possibilities and questions raised by HPPD: a broad, under-researched and not entirely uncommon condition in which people experience sustained and distressing changes to their visual perception (among other effects) after psychedelic trips. Ed has lived with these visual effects for nearly seven years, and is affiliated with a nonprofit launched last year to promote harm reduction around HPPD called the Perception Restoration Foundation.

Follow Ed at https://edprideaux.journoportfolio.com/
Visit the Perception Restoration Foundation at: Perception.Foundation

Some more info on perception as a hallucination: https://www.newstatesman.com/science-tech/2022/02/is-reality-a-hallucination-the-neuroscientist-anil-seth-thinks-so

Some of the studies mentioned in this episode:
The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act
https://pubmed.ncbi.nlm.nih.gov/29753748/
Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants
https://pubmed.ncbi.nlm.nih.gov/35076721/
Adverse effects of psychedelics: From anecdotes and misinformation to systematic science
https://doi.org/10.1177%2F02698811211069100

If you liked this episode, here are others you might enjoy:
Episode 57: Autism, Acid and the Altered Brain with Aaron Orsini and Justine Lee
Episode 64: LSD And Psilocybin For Physical Pain? with Greg McKee and Dr. Johannes Ramaekers
Episode 59: Psychedelic Extinction—How Poaching Endangers Some Psychoactive Plants with Dr. Anya Ermakova

Follow Narcotica on Instagram, Facebook, Twitter, YouTube and support us on Patreon. We just opened a shop where you can order Narcotica merch: narcocast.myshopify.com Help keep this podcast ad-free! Your support is appreciated! We’re on Spotify, iTunes, Stitcher and more. Tell your friends about us! Rate us! And thanks for your support!

*Note: Troy says niacin is Vitamin C, it’s actually Vitamin B3. We regret the error.

Producers: Christopher Moraff, Troy Farah, Zachary Siegel
Co-producer: Aaron Ferguson
Music: Glass Boy / Nomad1
Intro voice: Jenny Schaye
Image: David J / Flickr // edit: Troy Farah

Episode 64: LSD And Psilocybin For Physical Pain? with Greg McKee and Dr. Johannes Ramaekers

November 3, 2021 Narcotica Episodes, Psychedelics 01:20:18 1 Comment

These days, there isn’t an ailment some Silicon Valley-esque startup is trying to treat with psychedelics. Of course you have depression, anxiety, addiction, PTSD and fear of death for the terminally ill—there’s some good data for treating all of that—but some of the more obscure treatments include anorexia and eating disorders, sexual dysfunction, dementia, and even rare conditions like fragile X syndrome.

Psychedelics are amazing drugs, but they’re not a panacea. It’s not that this research isn’t worth investigating, but how do you determine what’s just hype and what the actual potential of psilocybin, LSD, DMT, etc. really is?

It may be wise to be skeptical of psychedelics being used to treat physical pain. Yet while the research is very young, there is some fascinating evidence that psychedelics may help with chronic pain, fibromyalgia, cluster headaches and even phantom limb pain. And what’s interesting is so many different research institutions and corporations are exploring this question. It’s not exactly a fringe topic and Narcotica co-host Troy Farah dives in with two conversations.

The first is an interview with Greg McKee, CEO of Tryp Therapeutics, a California-based startup that is exploring chronic pain relief using psilocybin and another, psilocybin-based drug with an undisclosed formulation that is obliquely called TRP-8803. The company has partnered with the University of Michigan and the University of Wisconsin-Madison to study how these drugs might treat fibromyalgia and Tryp has added leading psychedelic researcher Robin Carhart-Harris to its scientific advisory board, where he will play a “critical role” in clinical trial design.

The second interview is with Dr. Johannes Ramaekers of Maastricht University, who says he is developing another pain study to look at psychedelics and fibromyalgia. He was the lead author of a very interesting study published in 2020 in the Journal of Psychopharmacology that found that quote “low doses of LSD might constitute a novel pharmacological therapy.”

Read Troy’s article in Scientific American here: https://www.scientificamerican.com/article/can-psychedelic-drugs-treat-physical-pain/

Read Dr. Ramaekers’ pain and LSD study here: https://doi.org/10.1177%2F0269881120940937

Learn more about Tryp Therapeutics at https://tryptherapeutics.com/

If you liked this episode, here are others you might enjoy:
Episode 41: What Does It All Ketamine? with Dr. Erica Zelfand
Episode 49: Salvia: Psychedelic Oddity (Plus, Canada’s Emerging Psilocybin Scene)
Episode 25: Banning Kratom Will Escalate the Opioid Overdose Crisis with Walter Prozialeck

Follow Narcotica on Instagram, Facebook, Twitter, YouTube and support us on Patreon. Help keep this podcast ad-free! Your support is appreciated! We’re on Spotify, iTunes, Stitcher and more. Tell your friends about us! Rate us! And thanks for your support!

Producers: Christopher Moraff, Troy Farah, Zachary Siegel
Co-producer: Garrett Farah
Music: Glass Boy
Intro voice: Jenny Schaye
Image: PXFuel // The Noun Project // edit: Troy Farah

Episode 57: Autism, Acid and the Altered Brain with Aaron Orsini and Justine Lee

May 23, 2021 Narcotica Episodes 00:57:25 0 Comments

For many people, psychedelic drugs like LSD or psilocybin are their first major introduction to a profoundly altered state of consciousness. Mental conditions like autism or ADHD are other forms of consciousness, although they don’t wear off after 12 hours and so-called ‘neurotypical’ people often have misconceptions about these mental arrangements. Many folks with autism don’t see their condition as a defect or something to be fixed, an attitude that has sparked the neurodiversity movement. But, autism does come with its own set of challenges, some especially find difficulty in socializing with others.

A very early body of scientific research suggests that psychedelics could help with some of the challenges of autism. MAPS, for example, has explored using MDMA to treat social anxiety caused by autism. But some folks with autism aren’t waiting for the science to catch up and are trying psychedelics to explore how it can help some of the challenging aspects of autism.

Narcotica co-host Troy Farah speaks with Aaron Orsini, author of the book Autism On Acid: How LSD Helped Me Understand, Navigate, Alter & Appreciate My Autistic Perceptions and Justine Lee, a graduate student in pharmacology at UC Irvine with a B.S. in neurobiology.

You can follow Aaron Orsini on Twitter: @AutismOnAcid and order the anthology Autistic Psychedelic here.

Troy also wrote about this in Filter Magazine, so you can read more about the up-to-date science on this topic and how scientists are studying psychedelics with autism.

Follow Narcotica on Facebook, Twitter and support us on Patreon. Your support is appreciated! We’re on Spotify, iTunes, YouTube, Stitcher and more. Tell your friends about us!

If you liked this episode, here are others you might enjoy:
Episode 49: Salvia: Psychedelic Oddity (Plus, Canada’s Emerging Psilocybin Scene)
Episode 35: Holding Space — The Values of Trip Sitting with Michelle Janikian
Episode 17: Using DMT To Contact Aliens

Producers: Christopher Moraff, Troy Farah, Zachary Siegel
Co-producer: Aaron Ferguson / Troy Farah
Music: Glass Boy / Vuyvch
Intro voice: Jenny Schaye
Image: Pixabay edit: Troy Farah

Episode 52: The Fundamental Human Right to Get High with Casey William Hardison

February 22, 2021 Narcotica Episodes 00:58:15 1 Comment

Maybe it seems like an obvious question, but why is certain drug use illegal in the first place? Don’t you, as a human being, have some bodily autonomy and doesn’t that extend to alterations in the mind as well? What about the fundamental right to change your mind?

On this episode of Narcotica, co-hosts Troy Farah, Chris Moraff and Zachary Siegel talk with Casey William Hardison about cognitive liberty, the freedom of thought, and how that relates to prohibiting some drugs but not others. Hardison is a giant in the underground chemistry scene, who has rubbed shoulders with many legends in obscure chemistry: Sasha Shulgin and Darrell Lemaire, for example, and he was featured on Hamilton’s Pharmacopeia, in the episode ‘The Lazy Lizard School of Hedonism.’

In the past, Casey operated several infamous drug labs producing things like MDMA, LSD and 2C-B. That’s all behind him, but unrelated to that, Casey has had a bit of legal trouble lately, which we’ll discuss more, but his central argument in court is quite unique. 

This episode is being produced in collaboration with Filter Magazine. Troy wrote an article that goes into some more detail about Casey’s life and the implications for this court case. You can read the article at filtermag.org

You can follow Casey on Twitter @asthouwilt

If you liked this episode, here are others you might enjoy:
Episode 49: Salvia: Psychedelic Oddity (Plus, Canada’s Emerging Psilocybin Scene)
Episode 15: Accurate, Compassionate Drug Journalism with Filter Magazine
Episode 17: Using DMT To Contact Aliens

Follow Narcotica on Facebook, Twitter and support us on Patreon. Your support is appreciated! We’re on Spotify, iTunes, YouTube, Stitcher and more. Tell your friends about us!

Producers: Christopher Moraff, Troy Farah, Zachary Siegel
Co-producer: Garrett Farah
Music: Glass Boy / Checkie Brown
Intro voice: Jenny Schaye
Image: Pixabay // edit: Troy Farah

Episode 49: Salvia: Psychedelic Oddity with Ivan Casselman (Plus, Canada’s Emerging Psilocybin Scene)

December 22, 2020 Narcotica Episodes 00:49:20 1 Comment

Most people know salvia as the weird psychedelic drug at head shops that you try once, have a bizarre, uncomfortable experience and never touch it again. But there’s so much more to salvia divinorum, psychedelics and plant medicine in general. Narcotica co-host Troy Farah speaks with Dr. Ivan Casselman, from Vancouver, B.C., Canada, who has a Ph.D. in Plant Science, studying their analytical chemistry and genetics and works as the Chief Psychedelics Officer for Havn Life Sciences.

We discuss all things salvia divinorum, including ethnobotany and indigenous use of this plant, its strange effects compared to ‘classic’ psychedelics like LSD, and how to safely use and understand this drug. Plus, we get into Canada’s evolving psychedelic scene and what the future might hold for entheogens in the Great White North.

Follow Dr. Ivan Casselman on Twitter @drivancasselman

If you liked this episode, here are others you might enjoy:
Episode 41: What Does It All Ketamine?
Episode 17: Using DMT To Contact Aliens
Episode 35: Holding Space — The Values of Trip Sitting

Follow Narcotica on Facebook, Twitter and support us on Patreon. Your support is appreciated! We’re on Spotify, iTunes, YouTube, Stitcher and more. Tell your friends about us!

Producers: Christopher Moraff, Troy Farah, Zachary Siegel
Co-producer: Garrett Farah
Music: Glass Boy / Chris Zabriskie
Image: Wikimedia Commons // edit: Troy Farah